Action Exploratoire INRIA Compartimentage

The COMPARTIMENTAGE project (INRIA Exploratory Action 2022-2024, 110kE) is led by Romain Yvienc within the MUSCA team, in collaboration with the SERPICO project team.

G protein-coupled receptors (GPCRs) form a large class of membrane receptors mainly targeted by therapeutic agents. Recently, it has been demonstrated that these receptors are capable of inducing cascades of biochemical reactions from pools of extremely dynamic intracellular compartments. The subcellular trafficking of receptors thus generates spatio-temporal heterogeneity in cell signaling, with a critical role on physiological functions, and profound consequences on the search for new therapeutic strategies.

In the COMPARTIMENTAGE project, we aim to develop new modeling formalisms, combining biochemical reaction networks and coagulation-fragmentation dynamics to fully represent the diversity and complexity of signaling pathways. By comparing our models to data from confocal microscopy imaging at super spatio-temporal resolution, we wish to reveal how the spatio-temporal heterogeneity of intracellular compartments conditions the response of cells to extracellular signals.