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I worked on molecular aspects of the HIV interaction with its human host receptor CD4 during my Master’s. My PHD, which revolved around the implementation of cell-free protein expression technology for structural applications, was carried at the Université de Grenoble-Alpes (UGA, France), with the small biotech company Synthelis, in collaboration between European Synchrotron Radiation Facility (ESRF) and Institut Laue–Langevin (ILL). I did my previous Post-Doc at the Institut de Biologie et Chimie des Protéines (IBCP, France) where I was responsible for structurally characterising the inhibition of critical Plasmodium falciparum enzymes by novel rationally designed molecules.
My work here is the based around the recombinant expression and purification of both the follicle stimulating hormorne receptor, and nanobodies that potentially interact with the receptor. I am then responsible for confirming the structural integrity of the proteins, and characterising their interactions. I generally make use of pull-down assays, thermal shift assays (TSA) and biolayer interferometry (BLI) in order to do so.

#Biais de signalisation