Frederic JEAN-ALPHONSE (CNRS Researcher)

Gonadotrophin receptors are key G protein-coupled receptors (GPCR) involved in the control of the biology of reproduction. Recently, LH/CG and FSH receptors were shown to signal not only from the plasma membrane but also from several endocytic compartments (early endosomes and very early endosomes). The functional importance of compartmentalized signalling and the underlying mechanisms remain elusive.
My research is interested at defining the spatial and temporal dynamics of intracellular signalling, identifying the mechanisms of receptor trafficking, elucidating the specific consequences of these dynamics on the various cellular processes and gonads physiology, and developing pharmacological approaches based on the antibody fragments technology to manipulate receptor activity.

#Compartmentalized signaling
#Multi-scale modeling
#Signaling Bias